Curcumin is a very important therapeutic agent in integrative medicine. We all know curcumin has an incredible array of preclinical and some early clinical research exploring its utility in a variety of diseases, but it is efficacy is often limited by its poor absorption. Intravenous administration is one way to help avoid this and get much higher concentrations to deliver better therapeutic efficacy. In this lesson, we will review the evidence behind curcumin's use from an intravenous perspective. We will discuss what types of clinical trials have been done that provide evidence both for the safe administration and management of patients receiving IV curcumin. We will talk about protocols for administration, safe dosing, and patient assessment and monitoring. This is an important prerequisite for referring patients to receive delegation for infusion of curcumin with ONIN.